A controlled, double-blind, randomized study on the eficacyof Lactiplantibacillus plantarum\u00a0DSM 9843 <\/em>in patients with irritable bowel syndrome Krzysztof Niedzielina, Hubert Kordeckia and Bozena Birkenfeldb European Journal of Gastroenterology & Hepatology 2001, 13:1143\u00b11147<\/em><\/p>\n Tested parameters<\/strong><\/p>\n Self grading, stomach pain, frequency and consistency of the stool and flatulence<\/p>\n Duration of study: 4 weeks<\/p>\n Design of the clinical study: 40 patients<\/p>\n Placebo group: 20 patients \u2013 5 males, 15 females<\/p>\n Flobian test group: 20 patients \u2013 3 males,17 females<\/p>\n FLOBIAN<\/strong>\u00a0<\/span>has a positive effect on the stomach pain with the patients who have irritable colone syndrome.<\/p>\n % percentage of people with abdominal pain<\/strong><\/p>\n at the end of the study<\/strong><\/p>\n FLOBIAN \u00a0<\/em><\/strong>has positive effects on all symptoms of irritable colone (pain, constipation diarrhea and flatulence)<\/p>\n CLINICAL STUDY II \u2013 Clinical study of the product Flobian in the therapy of the syndrome of Irritable colon<\/em><\/strong><\/p>\n Alteration of Intestinal Microflora Is Associated With Reduction in Abdominal Bloating and Pain in Patients With Irritable Bowel Syndrome.\u00a0<\/span><\/em><\/strong>Nobaek, M.D., Marie-Louise Johansson, Ph.D.,Molin, Ph.D., Siv Ahrne\u00b4, Ph.D., and Bengt Jeppsson, M.D., Ph.D., F.R.C.S. THE AMERICAN JOURNAL OF GASTROENTEROLOGY Vol.95, No. 5,2000\u00a9 2000 by Am. Coll. of Gastroenterology ISSN 00029270\/00\/$20.00<\/em><\/p>\n Tested parameters<\/strong><\/p>\n Once a week Visual Analog Scale (VAS): all functions of GIT, defecalisation, pain and flatulence.<\/p>\n Duration of study: 1 year,<\/p>\n Duration of treatment: 4 weeks,<\/p>\n Second control participants: After 12 months<\/p>\n Number of tested patients: 60 (8 patients were excluded from the study)<\/p>\n Placebo group : 27 patients,7 males i 20 females<\/p>\n Test group : 25 patients, 9 males i 16 females<\/p>\n 44% treated patients showed signs of reduced flatulence.<\/p>\n Only 18% of the patients in the placebo group noticed the reduction of flatulence.<\/p>\n Reduced excessive gasses.<\/p>\n FLOBIAN has positive effect on the reduction of flatulence at the test group.<\/p>\n Results<\/strong><\/p>\n Flobian\u00a0<\/em><\/strong>has positive effect on on defecation at the patients diagnosed with irritable colon.<\/em><\/p>\n Flobian has positive effect on all gastrointestinal functions of patients diagnosed with syndrome of irritable colon.<\/p>\n FLOBIAN: Scientifically proven efficiency!<\/em><\/strong><\/p>\n At patients with syndrome of Irritable Colon:<\/p>\n List of studies:<\/strong><\/p>\n Niedzielin, K., Kordecki, H and Birkenfeld, B. 2001. A controlled double-blind, randomized study on the efficacy of Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 <\/span>\u00a0in patients with irritable bowel syndrome.\u00a0<\/span>European Journal of Gastroenterology andl Hepatology\u00a0<\/span><\/em>13:1-5<\/a><\/p>\n Nobaek, S., Johansson, M.-L., Molin, G., Ahrn\u00e9, S. and Jeppsson, B. 2000. Alteration of intestinal microflora is associated with reduction in abdominal blaoting and pain in patients with irritable bowel syndrome (IBS).\u00a0<\/span>American Journal of Gastroenterology\u00a0<\/span><\/em>95: 1231-1238.<\/a><\/p>\n P. Samart, J. Venkatraman, P. Ducrott\u00e9 . Evaluation of Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 Efficacy in IBS: Results of a Randomized Placebo-Controlled Trial in 200 Patients. T2030- Poster Session: Prebiotics and probiotics in the intestine: activities and function. Digestive Disease Week 2010, New Orleans.<\/p>\n Bengmark, S. and Gianotti, L. 1996. Nutritional support to prevent and treat multiple organ failure.\u00a0<\/span>World Journal of Surgery\u00a0<\/span><\/em>20: 474-481.<\/a><\/p>\n Molin, G. 2001. Probiotics in food not containing milk or milk constituents, with special reference to Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843\u00a0<\/span>.\u00a0<\/span>American Journal of Clinical Nutrition\u00a0<\/span><\/em>73: 380S-385S<\/a><\/p>\n Molin, G., Jeppsson, B., Johansson, M.-L., Ahrn\u00e9, S., Nobaek, S., St\u00e5hl, M. and Bengmark, S. 1993. Numerical taxonomy of\u00a0<\/span>Lactobacillus\u00a0<\/span><\/em>spp. associated with healthy and diseased mucosa of the human intestines.\u00a0<\/span>Journal of Applied Bacteriology\u00a0<\/span><\/em>74: 314-323.<\/a><\/p>\n Johansson, M.-L., Quednau, M., Molin, G. and Ahrn\u00e9, S. 1995. Randomly Amplified Polymorphic DNA (RAPD) for rapid typing of\u00a0<\/span>Lactobacillus plantarum\u00a0<\/span><\/em>strains. Letters in Applied Microbiology\u00a0<\/span><\/em>21: 155-159.<\/a><\/p>\n Ahrn\u00e9, S., Nobaek, S., Jeppsson, B., Adlerberth, I., Wold, A.E and Molin, G. 1998. The normal\u00a0<\/span>Lactobacillus\u00a0<\/span><\/em>flora of healthy human rectal and oral mucosa.\u00a0<\/span>Journal of Applied Microbiology\u00a0<\/span><\/em>85: 88-94.<\/a><\/p>\n Kasravi, F.B., Adawi, D., Molin, G., Bengmark, S. and Jeppsson, B. 1996. Effect of oral supplementation of lactobacilli on bacterial translocation in acute liver injury induced by D-galactoseamine.\u00a0<\/span>Journal of Hepatology\u00a0<\/span><\/em>26: 417-424.<\/p>\n Mao, Y., Nobaek, S., Kasravi, B., Adawi, D., Stenram, U., Molin, G. and Jeppsson, B. 1996. The effects of\u00a0<\/span>Lactobacillus\u00a0<\/span><\/em>strains and oat fiber on Methotrexate-induced enterocolitis in rats.\u00a0<\/span>Gastroenterology\u00a0<\/span><\/em>111: 334-344.<\/p>\n Adawi D, Kasravi FB, Molin G, Jeppsson B. 1997. Effect of Lactobacillus supplementation with and without arginine on liver damage and bacterial translocation in an acute liver injury model in the rat. Hepatology. 1997 Mar;25(3):642-7. PMID: 9049212 [PubMed \u2013 indexed for MEDLINE]<\/a><\/p>\n Adawi, D., Molin, G., Jeppson, B. 1999. Inhibition of Nitric Oxide Production and the Effects of Arginine and Lactobacillus Administration in an Acute Liver Injury Model. Annals of Surgery. Vol. 228, No. 6, 748-755.<\/a><\/p>\n Herias, M.V., Hessle, C., Midtvedt, T., Hanson, L.\u00c5. and Wold A.E. 1999. Immunomodulatory effects of\u00a0<\/span>Lactobacillus plantarum\u00a0<\/span><\/em>colonizing the intestine of gnotobiotic rats.\u00a0<\/span>Clinical Experimental Immunology\u00a0<\/span><\/em>116: 283-290.<\/a><\/p>\n Mangiante, G., Colucci, G., Canepari, P., Bassi, C., Nicoli, N., Casaril, A., Marinello, P., Signoretto, C. and Bengmark, S. 2001.\u00a0<\/span>Lactobacillus plantarum\u00a0<\/span><\/em>reduces infection of pancreatic necrosis in experimental acute pancreatitis.\u00a0<\/span>Digestive Surgery\u00a0<\/span><\/em>18: 47-50<\/a><\/p>\n Mangell, P., Nejdfors, P., Wang, M., Ahrn\u00e9 S., Westr\u00f6m B., Thorlacius, H. and Jeppsson, B. Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 <\/span>\u00a0Inhibits\u00a0<\/span>Esherichia coli<\/em>\u2013 Induced intestinal Permeability.\u00a0<\/span>Digestive Diseases and Sciences 2002; 47: 511-516<\/em><\/a><\/p>\n Schultz, M., Veltkamp, C., Dieleman, L. A., Grenther, W. B., Wyrick, P. B., Tonkonogy, S. L. and Sartor, R. B. 2002 Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 <\/span>\u00a0in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice.\u00a0<\/span>Inflammatory Bowel Disease\u00a0<\/span><\/em>8(2): 71-80.<\/a><\/p>\n Osman N, Adawi D, Ahrne S, Jeppsson B, Molin G. 2004 Modulation of the effect of dextran sulfate sodium-induced acute colitis by the administration of different probiotic strains of Lactobacillus and Bifidobacterium. Dig Dis Sci Feb;49(2):320-7<\/a><\/p>\n Osman N, Adawi D, Molin G, Ahrne S, Berggren A, Jeppsson B. 2006 Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis inrats. BMC Gastroenterol. 28;6:31.<\/a><\/p>\n Mangell P, Lennernas P, Wang M, Olsson C, Ahrne S, Molin G, Thorlacius H, Jeppsson B. 2006 Adhesive capability of Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 is important for preventing bacterial translocation in endotoxemic rats. APMIS. Sep;114(9):611-8<\/a><\/p>\n Hakansson A, Stene C, Mihaescu A, Molin G, Ahrne S, Thorlacius H, Jeppsson B. 2006 Rose hip and Lactobacillus plantarum DSM 9843 reduce ischemia\/reperfusion injury in the mouse colon. Nov;51(11):2094-101. Epub 2006 Sep 29<\/a><\/p>\n Nishikawara F, Katsumura S, Ando A, Tamaki Y, Nakamura Y, Sato K, Nomura Y, Hanada N. 2006 Correlation of cariogenic bacteria and dental caries in adults. J. Oral Sci. Vol.48, No.4, 245-251.<\/p>\n F\u00e5k F, Ahrn\u00e9 S, Linderoth A, Molin G, Jeppsson B, Westr\u00f6m B. 2007. Agerelated Effects of the Probiotic Bacterium Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 on Gastrointestinal Function in Suckling Rats. Dig Dis Sci. 7; [Epub ahead of print]<\/a><\/p>\n Johansson, M.-L., Molin; G., Jeppsson, B., Nobaek, S., Ahrn\u00e9, S. and Bengmark, S. 1993. Administration of different\u00a0<\/span>Lactobacillus\u00a0<\/span><\/em>strains in fermented oatmeal soup:\u00a0<\/span>in vivo\u00a0<\/span><\/em>colonization of human intestinal mucosa and effect on the indigenous flora.\u00a0<\/span>Applied and Environmental Microbiology\u00a0<\/span><\/em>59: 15-20.<\/a><\/p>\n Vanderhoof, J. A., Young, J. R., Murray, N. and Kaufman, S. S. 1998. Treatment strategies for small bowel bacterial overgrowth in short bowel syndrome.\u00a0<\/span>Journal of Pediatric Gastroenterology and Nutrition<\/em>, 27: 155-160.<\/a><\/p>\n Johansson, M.-L., Nobaek, S., Berggren, A., Jeppsson, B., Ahrn\u00e9, S., Nyman, M., Bj\u00f6rck, I. and Molin, G. 1998. Survival of Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 <\/span>, and effect on the short-chain fatty acid content of faeces after ingestion of a rose-hip drink with fermented oats.\u00a0<\/span>International Journal of Food Microbiology\u00a0<\/span><\/em>42: 29-38.<\/p>\n Kingamkono, R., Sj\u00f6gren, E. and Svanberg, U. 1999. Enteropathogenic bacteria in faecal swabs of young children fed on lactic-acid fermented cereal gruels.\u00a0<\/span>Epidemiology and Infection\u00a0<\/span><\/em>122: 23-32<\/a><\/p>\n Stjernquist-Desantik, A., Warfving, H. and Johansson, M-L. 2000. Persistence of\u00a0<\/span>Lactobacillus plantarum\u00a0<\/span><\/em>DSM 9843 on Human Tonsillar Surface after Oral Administration in Fermented Oatmeal Gruel.\u00a0<\/span>Acta Otolaryngol<\/em>, Suppl 543: 215-219<\/a><\/p>\n Naruszewicz, M., Johansson, M-L., Zapolska-Downar, D. and Bukowska, H. 2002. Effect of Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 <\/span>\u00a0on cardiovascular risk factors in smokers.\u00a0<\/span>American Journal of Clinical Nutrition \u2013<\/em>76: 1249-55.<\/a><\/p>\n \u00d6nning, G, Berggren, A, Drevelius, M., Jeppsson, B., Lindberg, A-M and Johansson Hagsl\u00e4tt, M-L. 2003. Influence of a drink containing different antioxidants and Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 <\/span>\u00a0on plasma total antioxidant capacity, selenium status and faecal microbial flora.\u00a0<\/span>International Journal of Food Sciences and Nutrition, Vol.54, No.4:281-289<\/em><\/a><\/p>\n Wullt, M., Johansson Hagsl\u00e4tt, M.-L. & Odenholt, I. (2003) Lactiplantibacillus plantarum<\/em>\u00a0DSM 9843 <\/span>\u00a0for the treatment of recurrent clostridium difficile-associated diarrhoea: A double-blind, placebo-controlled trial.\u00a0<\/span>Scandinavian Journal of Infectious Diseases 35: 365-367<\/em><\/p>\n\n
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